Blar i forfatter "Lazado, Carlo C."

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    • Acute dose-response exposure of a peracetic acid-based disinfectant to Atlantic salmon parr reared in recirculating aquaculture systems 

      Mota, Vasco; Eggen, Maia L.; Lazado, Carlo C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-15)
      There is a high regard for peracetic acid (PAA)-based disinfectants in recirculating aquaculture systems (RAS) because of the low risk of bioaccumulation, fast degradation with neutral residuals and minimal impact on biofilter performance. However, the no-observed-effect concentration in Atlantic salmon parr is unknown. The present study evaluated the effect of an acute PAA exposure on Atlantic ...

    • Embracing prospects for reducing the numbers of animals used in aquaculture research 

      Lazado, Carlo C.; Ytteborg, Elisabeth; Noble, Christopher (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-29)
      The principles of three Rs-REPLACEMENT, REDUCTION, and REFINEMENT-govern the protection and use of animals, including fish, for research purposes in the European Union and Norway. In this paper, we discuss some straightforward steps to simplify the delivery of these principles at the idea stage and adapt some of these examples for conducting fish trials related to health and welfare. Although some ...

    • Mucosal and systemic physiological changes underscore the welfare risks of environmental hydrogen sulphide in post-smolt Atlantic salmon (Salmo salar) 

      Lazado, Carlo C.; Stiller, Kevin Torben; Timmerhaus, Gerrit; Reiten, Britt Kristin Megård; Nicolaysen, Ilona Lorraine; Carletto, Danilo; Alipio, Hanna Ross De Dios; Hansen-Bergstedt, Julie; Andersen, Øivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-04)
      Atlantic salmon (Salmo salar) might encounter toxic hydrogen sulphide (H<sub>2</sub>S) gas during aquaculture production. Exposure to this gas can be acute or chronic, with heightened levels often linked to significant mortality rates. Despite its recognised toxicity, our understanding of the physiological implications of H<sub>2</sub>S on salmon remains limited. This report details the mucosal and ...

    • Oxidant-induced modifications in the mucosal transcriptome and circulating metabolome of Atlantic salmon 

      Lazado, Carlo C.; Pedersen, Lars-Flemming; Kirste, Katrine H.; Soleng, Malene; Breiland, Mette Serine Wesmajervi; Timmerhaus, Gerrit (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-06)
      Here we report the molecular networks associated with the mucosal and systemic responses to peracetic acid (PAA), a candidate oxidative chemotherapeutic in Atlantic salmon (<i>Salmo salar</i>). Smolts were exposed to different therapeutic doses (0, 0.6 and 2.4 mg/L) of PAA for 5 min, followed by a re-exposure to the same concentrations for 30 min 2 weeks later. PAA-exposed groups have higher external ...

    • Peracetic acid as a potential treatment for amoebic gill disease (AGD) in Atlantic salmon - Stage 1 

      Lazado, Carlo C.; Timmerhaus, Gerrit; Pedersen, Lars-Flemming; Pittman, Karin; Soleng, Malene; Haddeland, Sindre; Johansen, Lill-Heidi; Breiland, Mette Serine Wesmajervi; Rørmark, Lisbeth; Mohammad, Saima; Hytterød, Sigurd (Research report; Forskningsrapport, 2019-06)
      PERAGILL is an initiative that ultimately aims to develop an alternative treatment for the currently available therapies for amoebic gill disease (AGD) that have several practical and environmental issues. Peracetic acid (PAA) is a potent oxidant with a broad spectrum of antimicrobial activity and decays into relatively safe residuals, thus, has been widely recognised as a sustainable disinfectant ...